Cell Density-Dependent Regulation of Hepatic Development by a gp130-Independent Pathway
Identifieur interne : 000B21 ( Main/Exploration ); précédent : 000B20; suivant : 000B22Cell Density-Dependent Regulation of Hepatic Development by a gp130-Independent Pathway
Auteurs : Nobuhiko Kojima [Japon] ; Taisei Kinoshita [Japon] ; Akihide Kamiya [Japon] ; Koji Nakamura [Japon] ; Kinichi Nakashima [Japon] ; Tetsuya Taga [Japon] ; Atsushi Miyajima [Japon]Source :
- Biochemical and Biophysical Research Communications [ 0006-291X ] ; 2000.
English descriptors
- KwdEn :
Abstract
We previously demonstrated that oncostatin M (OSM) promotes hepatic development in concert with glucocorticoid. The livers from mice deficient for gp130, a signaling subunit of the OSM receptor, displayed reduced expression of hepatic differentiation marker and defective glycogenic function. However, these phenotypes were not completely abolished in gp130−/− mice, suggesting that there is an alternative pathway regulating hepatic development in vivo. To test this possibility, we cultured gp130−/− fetal hepatic cells and investigated a signal that induces hepatic differentiation. When hepatocytes were forced to interact with each other by inoculating cells at high densities, hepatic differentiation was induced even in the absence of gp130. Moreover, cells stimulated with OSM and/or cultured at a high density possess many other metabolic functions. These observations suggest that fetal hepatic cells acquire multiple characteristics of differentiated hepatocytes in response to the signals generated by cell–cell contacts as well as by OSM.
Url:
DOI: 10.1006/bbrc.2000.3635
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cell Density-Dependent Regulation of Hepatic Development by a gp130-Independent Pathway</title><author><name sortKey="Kojima, Nobuhiko" sort="Kojima, Nobuhiko" uniqKey="Kojima N" first="Nobuhiko" last="Kojima">Nobuhiko Kojima</name></author><author><name sortKey="Kinoshita, Taisei" sort="Kinoshita, Taisei" uniqKey="Kinoshita T" first="Taisei" last="Kinoshita">Taisei Kinoshita</name></author><author><name sortKey="Kamiya, Akihide" sort="Kamiya, Akihide" uniqKey="Kamiya A" first="Akihide" last="Kamiya">Akihide Kamiya</name></author><author><name sortKey="Nakamura, Koji" sort="Nakamura, Koji" uniqKey="Nakamura K" first="Koji" last="Nakamura">Koji Nakamura</name></author><author><name sortKey="Nakashima, Kinichi" sort="Nakashima, Kinichi" uniqKey="Nakashima K" first="Kinichi" last="Nakashima">Kinichi Nakashima</name></author><author><name sortKey="Taga, Tetsuya" sort="Taga, Tetsuya" uniqKey="Taga T" first="Tetsuya" last="Taga">Tetsuya Taga</name></author><author><name sortKey="Miyajima, Atsushi" sort="Miyajima, Atsushi" uniqKey="Miyajima A" first="Atsushi" last="Miyajima">Atsushi Miyajima</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:DA3F8E94894E6872E289E68E2BEF99E581386E01</idno><date when="2000" year="2000">2000</date><idno type="doi">10.1006/bbrc.2000.3635</idno><idno type="url">https://api.istex.fr/document/DA3F8E94894E6872E289E68E2BEF99E581386E01/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000522</idno><idno type="wicri:Area/Main/Curation">000519</idno><idno type="wicri:Area/Main/Exploration">000B21</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Exploration">000B21</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Cell Density-Dependent Regulation of Hepatic Development by a gp130-Independent Pathway</title><author><name sortKey="Kojima, Nobuhiko" sort="Kojima, Nobuhiko" uniqKey="Kojima N" first="Nobuhiko" last="Kojima">Nobuhiko Kojima</name><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo-ku, Tokyo, 113-0032</wicri:regionArea><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Kinoshita, Taisei" sort="Kinoshita, Taisei" uniqKey="Kinoshita T" first="Taisei" last="Kinoshita">Taisei Kinoshita</name><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo-ku, Tokyo, 113-0032</wicri:regionArea><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Kamiya, Akihide" sort="Kamiya, Akihide" uniqKey="Kamiya A" first="Akihide" last="Kamiya">Akihide Kamiya</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>KAST Stem Cell Regulation Project, Teikyo University Biotechnology Research Center, Miyamae-ku, Kawasaki, 216-0001</wicri:regionArea><wicri:noRegion>216-0001</wicri:noRegion></affiliation></author><author><name sortKey="Nakamura, Koji" sort="Nakamura, Koji" uniqKey="Nakamura K" first="Koji" last="Nakamura">Koji Nakamura</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>KAST Stem Cell Regulation Project, Teikyo University Biotechnology Research Center, Miyamae-ku, Kawasaki, 216-0001</wicri:regionArea><wicri:noRegion>216-0001</wicri:noRegion></affiliation></author><author><name sortKey="Nakashima, Kinichi" sort="Nakashima, Kinichi" uniqKey="Nakashima K" first="Kinichi" last="Nakashima">Kinichi Nakashima</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Molecular Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo, 101-0062</wicri:regionArea><wicri:noRegion>101-0062</wicri:noRegion></affiliation></author><author><name sortKey="Taga, Tetsuya" sort="Taga, Tetsuya" uniqKey="Taga T" first="Tetsuya" last="Taga">Tetsuya Taga</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Molecular Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo, 101-0062</wicri:regionArea><wicri:noRegion>101-0062</wicri:noRegion></affiliation></author><author><name sortKey="Miyajima, Atsushi" sort="Miyajima, Atsushi" uniqKey="Miyajima A" first="Atsushi" last="Miyajima">Atsushi Miyajima</name><affiliation wicri:level="4"><country xml:lang="fr">Japon</country><wicri:regionArea>Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo-ku, Tokyo, 113-0032</wicri:regionArea><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Biochemical and Biophysical Research Communications</title><title level="j" type="abbrev">YBBRC</title><idno type="ISSN">0006-291X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">277</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="152">152</biblScope><biblScope unit="page" to="158">158</biblScope></imprint><idno type="ISSN">0006-291X</idno></series><idno type="istex">DA3F8E94894E6872E289E68E2BEF99E581386E01</idno><idno type="DOI">10.1006/bbrc.2000.3635</idno><idno type="PII">S0006-291X(00)93635-0</idno><idno type="ArticleID">93635</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-291X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>STAT3</term><term>cell density</term><term>gp130</term><term>hepatic development</term><term>knockout mouse</term><term>metabolic function</term><term>oncostatin M</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We previously demonstrated that oncostatin M (OSM) promotes hepatic development in concert with glucocorticoid. The livers from mice deficient for gp130, a signaling subunit of the OSM receptor, displayed reduced expression of hepatic differentiation marker and defective glycogenic function. However, these phenotypes were not completely abolished in gp130−/− mice, suggesting that there is an alternative pathway regulating hepatic development in vivo. To test this possibility, we cultured gp130−/− fetal hepatic cells and investigated a signal that induces hepatic differentiation. When hepatocytes were forced to interact with each other by inoculating cells at high densities, hepatic differentiation was induced even in the absence of gp130. Moreover, cells stimulated with OSM and/or cultured at a high density possess many other metabolic functions. These observations suggest that fetal hepatic cells acquire multiple characteristics of differentiated hepatocytes in response to the signals generated by cell–cell contacts as well as by OSM.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement><orgName><li>Université de Tokyo</li></orgName></list><tree><country name="Japon"><region name="Région de Kantō"><name sortKey="Kojima, Nobuhiko" sort="Kojima, Nobuhiko" uniqKey="Kojima N" first="Nobuhiko" last="Kojima">Nobuhiko Kojima</name></region><name sortKey="Kamiya, Akihide" sort="Kamiya, Akihide" uniqKey="Kamiya A" first="Akihide" last="Kamiya">Akihide Kamiya</name><name sortKey="Kinoshita, Taisei" sort="Kinoshita, Taisei" uniqKey="Kinoshita T" first="Taisei" last="Kinoshita">Taisei Kinoshita</name><name sortKey="Miyajima, Atsushi" sort="Miyajima, Atsushi" uniqKey="Miyajima A" first="Atsushi" last="Miyajima">Atsushi Miyajima</name><name sortKey="Nakamura, Koji" sort="Nakamura, Koji" uniqKey="Nakamura K" first="Koji" last="Nakamura">Koji Nakamura</name><name sortKey="Nakashima, Kinichi" sort="Nakashima, Kinichi" uniqKey="Nakashima K" first="Kinichi" last="Nakashima">Kinichi Nakashima</name><name sortKey="Taga, Tetsuya" sort="Taga, Tetsuya" uniqKey="Taga T" first="Tetsuya" last="Taga">Tetsuya Taga</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Musique/explor/SchutzV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B21 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000B21 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Musique
|area= SchutzV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:DA3F8E94894E6872E289E68E2BEF99E581386E01
|texte= Cell Density-Dependent Regulation of Hepatic Development by a gp130-Independent Pathway
}}
| This area was generated with Dilib version V0.6.38. |  |